ZNF446

Across TCGA patient cohorts, ZNF446 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,883 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ZNF446-associated proteins across cancer lineages are VEZF1, TRIM28, and CBX8. Each is linked with ZNF446 in more than 7 cancer types. Because this analysis shows association rather than direction, both ZNF446-to-partner and partner-to-ZNF446 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ZNF446 versus VEZF1 in BRCA, with a Pearson correlation of 0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF446→partner) and Y-score (partner→ZNF446) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VEZF1 →	+0.556	+0.560	<.001	<.001	3	8
OV	TRIM28 →	+0.408	+0.467	<.001	<.001	3	7
HNSC	CBX8 →	+0.460	+0.730	<.001	<.001	3	6
LSCC	NONO →	+0.171	+0.473	.003	<.001	3	6
BRCA	PNKP →	+0.350	+0.555	<.001	<.001	3	6
OV	UBE2M →	+0.322	+0.507	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,883 associations by consensus.

ZNF446 vs VEZF1 — BRCA

Explore this scatter interactively →