ZNF446

Across TCGA patient cohorts, ZNF446 protein abundance is significantly associated with the RNA expression of many other genes, with 9,699 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible ZNF446-associated genes across cancer lineages are ATP8B4, RELT, and TMSB10. Each is linked with ZNF446 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF446-to-partner and partner-to-ZNF446 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ZNF446 versus ATP8B4 in PDAC, with a Pearson correlation of -0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF446→partner) and Y-score (partner→ZNF446) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ATP8B4 →	-0.619	-0.457	<.001	<.001	3	3
PDAC	RELT →	-0.638	-0.362	<.001	.002	3	3
BRCA	TMSB10 →	-0.721	-0.399	<.001	<.001	3	3
BRCA	ARHGAP22 →	-0.707	-0.508	<.001	<.001	3	3
GBM	FCHO1 →	-0.762	-0.462	<.001	.001	3	3
BRCA	LINC00472 →	+0.884	+0.331	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,699 associations by consensus.

ZNF446 vs ATP8B4 — PDAC

Explore this scatter interactively →