ZNF446

Across TCGA cell cohorts, ZNF446 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,323 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF446-associated GO terms across cancer lineages are Cilium or flagellum-dependent cell motility, Protein polyubiquitination, and Positive regulation of intracellular steroid hormone receptor signaling pathway. Each is linked with ZNF446 in more than 14 cancer types. Because this analysis shows association rather than direction, both ZNF446-to-partner and partner-to-ZNF446 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cilium or flagellum-dependent cell motility grouped by ZNF446-low versus ZNF446-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF446→partner) and Y-score (partner→ZNF446) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Cilium or flagellum-dependent cell motility →	-0.100	-0.830	<.001	<.001	3	15
STOMACH	Protein polyubiquitination →	+0.067	+1.201	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.115	+0.705	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Cilium-dependent cell motility →	-0.100	-0.830	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Cilium movement involved in cell motility →	-0.104	-0.830	<.001	<.001	3	15
STOMACH	Regulation of TOR signaling →	+0.075	+1.016	.006	.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,323 associations by consensus.

Cilium or flagellum-dependent cell motility by ZNF446 expression — UPPER_AERODIGESTIVE_TRACT

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