ZNF446

Across TCGA cell cohorts, ZNF446 mutation is significantly associated with the RNA expression of many other genes, with 98 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF446-associated genes across cancer lineages are BCAS2, SERAC1, and NQO2. Each is linked with ZNF446 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF446-to-partner and partner-to-ZNF446 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BCAS2 grouped by ZNF446-low versus ZNF446-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF446→partner) and Y-score (partner→ZNF446) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BCAS2 →	+0.623	+3.212	.001	.006	3	1
LARGE_INTESTINE	SERAC1 →	+0.657	+3.212	.003	.006	3	1
LARGE_INTESTINE	NQO2 →	+0.993	+3.212	.004	.006	3	1
LARGE_INTESTINE	RNF138 →	+0.775	+3.212	.002	.006	3	1
LARGE_INTESTINE	TKTL2 →	+0.033	+2.924	.002	.002	3	1
LARGE_INTESTINE	TRIM36 →	+0.974	+3.299	.007	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 98 associations by consensus.

BCAS2 by ZNF446 expression — LARGE_INTESTINE

Explore this box plot interactively →