Across TCGA patient cohorts, ZNF445 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF445-associated genes across cancer lineages are PCNA, Shc_pY317, and ASNS. Each is linked with ZNF445 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF445-to-partner and partner-to-ZNF445 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF445→partner) and Y-score (partner→ZNF445) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.272	+2.263	<.001	<.001	3	3
UCEC	Shc_pY317 →	-0.154	-2.502	.002	.001	3	3
COAD	ASNS →	+0.607	+2.815	.005	.036	3	3
UCEC	ATM →	-0.532	-2.263	<.001	<.001	3	3
UCEC	c-Kit →	-0.192	-1.938	.012	.001	3	3
STAD	SF2 →	+0.394	+2.828	.040	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

Exploration

ZNF445 survival (RNA) · tumor vs normal (RNA) · all ZNF445 data types