Across TCGA cell cohorts, ZNF445 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF445-associated genes across cancer lineages are GUCA1C, CCL11, and ADRA1A. Each is linked with ZNF445 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF445-to-partner and partner-to-ZNF445 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF445→partner) and Y-score (partner→ZNF445) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GUCA1C →	+0.045	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	CCL11 →	+0.028	+4.867	<.001	.009	3	1
LARGE_INTESTINE	ADRA1A →	+0.125	+3.103	.003	.004	3	1
LARGE_INTESTINE	ETNPPL →	+0.302	+4.021	<.001	.001	3	1
LARGE_INTESTINE	KCTD8 →	+0.242	+3.832	<.001	<.001	3	1
LARGE_INTESTINE	C16orf96 →	+0.604	+3.520	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration

ZNF445 survival (RNA) · tumor vs normal (RNA) · all ZNF445 data types