Across TCGA patient cohorts, ZNF442 mutation is significantly associated with the RNA expression of many other genes, with 3,260 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF442-associated genes across cancer lineages are ALAS1, GUCA1B, and DHDDS. Each is linked with ZNF442 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF442-to-partner and partner-to-ZNF442 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF442→partner) and Y-score (partner→ZNF442) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ALAS1 →	+0.433	+2.321	<.001	<.001	3	3
UCEC	GUCA1B →	+0.488	+2.343	<.001	<.001	3	3
UCEC	DHDDS →	+0.333	+2.102	<.001	<.001	3	3
UCEC	WRAP53 →	+0.365	+1.699	.001	<.001	3	3
UCEC	FCGBP →	-0.789	-2.376	.001	<.001	3	2
BRCA	LINC00613 →	+0.712	+3.692	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,260 associations by consensus.

Exploration

ZNF442 survival (RNA) · tumor vs normal (RNA) · all ZNF442 data types