Across TCGA patient cohorts, ZNF441 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF441-associated genes across cancer lineages are JNK_pT183_Y185, p53, and PCNA. Each is linked with ZNF441 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF441-to-partner and partner-to-ZNF441 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF441→partner) and Y-score (partner→ZNF441) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.202	-2.807	<.001	.002	3	2
UCEC	p53 →	-0.282	-2.999	.029	.035	3	2
UCEC	PCNA →	+0.235	+2.502	.001	.001	3	2
UCEC	VHL →	-0.936	-1.874	<.001	.002	3	2
UCEC	ATM →	-0.627	-2.893	<.001	.001	3	2
UCEC	C-Raf →	+0.147	+1.584	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Exploration

ZNF441 survival (RNA) · tumor vs normal (RNA) · all ZNF441 data types