ZNF439

Across TCGA patient cohorts, ZNF439 mutation is significantly associated with the RNA expression of many other genes, with 4,122 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF439-associated genes across cancer lineages are RNU6-893P, PSMG3, and ARSK. Each is linked with ZNF439 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF439-to-partner and partner-to-ZNF439 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-893P grouped by ZNF439-low versus ZNF439-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF439→partner) and Y-score (partner→ZNF439) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RNU6-893P →	+0.733	+4.445	<.001	.005	3	4
UCEC	PSMG3 →	+0.287	+1.243	.003	.008	3	3
UCEC	ARSK →	+0.307	+1.595	.007	<.001	3	3
UCEC	PHF23 →	+0.367	+1.617	<.001	<.001	3	3
UCEC	CDKN3 →	+0.752	+2.247	<.001	<.001	3	3
UCEC	AP1S1 →	+0.352	+1.794	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,122 associations by consensus.

RNU6-893P by ZNF439 expression — READ

Explore this box plot interactively →