ZNF439

Across TCGA patient cohorts, ZNF439 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF439-associated genes across cancer lineages are eEF2, GAPDH, and Notch1. Each is linked with ZNF439 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF439-to-partner and partner-to-ZNF439 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ZNF439-low versus ZNF439-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF439→partner) and Y-score (partner→ZNF439) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.385	+1.530	<.001	.004	3	2
UCEC	GAPDH →	+0.429	+1.678	.008	.019	3	2
UCEC	Notch1 →	+0.134	+1.205	.001	.049	3	2
UCEC	RAD51 →	+0.098	+2.321	.020	.005	3	2
UCEC	TFRC →	+0.504	+1.530	.001	.004	3	2
UCEC	ASNS →	+0.347	+2.321	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

eEF2 by ZNF439 expression — UCEC

Explore this box plot interactively →