ZNF438

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, ZNF438 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF438-associated genes across cancer lineages are PCNA, GAPDH, and GATA6. Each is linked with ZNF438 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF438-to-partner and partner-to-ZNF438 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF438→partner) and Y-score (partner→ZNF438) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECPCNA →+0.253+2.415<.001.00333
UCECGAPDH →+0.389+1.874.036.04932
UCECGATA6 →-0.113-3.307.039.00932
UCECNotch1 →+0.135+1.440.005.02432
UCECp38-MAPK_pT180_Y182 →-0.377-2.000.015.00932
UCECPDCD4 →-0.594-2.070<.001.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

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