Across TCGA cell cohorts, ZNF438 mutation is significantly associated with the RNA expression of many other genes, with 184 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF438-associated genes across cancer lineages are CENPVL3, BHLHE23, and HMHB1. Each is linked with ZNF438 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF438-to-partner and partner-to-ZNF438 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF438→partner) and Y-score (partner→ZNF438) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CENPVL3 →	+0.160	+2.505	<.001	.003	3	2
LUNG_NSCLC_LUAD	BHLHE23 →	+0.049	+3.947	<.001	.004	3	1
LUNG_NSCLC_LUAD	HMHB1 →	+0.070	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR10AG1 →	+0.025	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	PABPC1L2B →	+0.029	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	NLRP2B →	+0.305	+4.169	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 184 associations by consensus.

Exploration

ZNF438 survival (RNA) · tumor vs normal (RNA) · all ZNF438 data types