ZNF432

Across TCGA patient cohorts, ZNF432 mutation is significantly associated with the RNA expression of many other genes, with 3,720 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF432-associated genes across cancer lineages are CORT, FTH1P27, and ATF4P2. Each is linked with ZNF432 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF432-to-partner and partner-to-ZNF432 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CORT grouped by ZNF432-low versus ZNF432-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF432→partner) and Y-score (partner→ZNF432) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CORT →	+0.394	+1.831	<.001	.002	3	3
SKCM	FTH1P27 →	+0.090	+3.655	<.001	.001	3	2
READ	ATF4P2 →	+0.072	+5.179	<.001	.001	3	2
CESC	MTND5P35 →	+0.028	+5.539	<.001	.004	3	2
READ	RNU4-65P →	+0.346	+5.257	<.001	.002	3	2
READ	DNM1P33 →	+0.233	+4.280	.004	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,720 associations by consensus.

CORT by ZNF432 expression — UCEC

Explore this box plot interactively →