ZNF432

Across TCGA patient cohorts, ZNF432 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF432-associated genes across cancer lineages are ATM, 4E-BP1, and GAPDH. Each is linked with ZNF432 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF432-to-partner and partner-to-ZNF432 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ZNF432-low versus ZNF432-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF432→partner) and Y-score (partner→ZNF432) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.501	-2.991	.013	.036	3	4
UCEC	4E-BP1 →	+0.272	+2.730	.002	.003	3	2
COAD	GAPDH →	+0.810	+3.008	.001	.019	2	2
COAD	Claudin-7 →	+0.677	+3.008	.049	.019	3	1
UCEC	eIF4E →	+0.171	+2.502	.015	.001	3	1
UCEC	ERK2 →	+0.150	+1.321	.020	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ATM by ZNF432 expression — COAD

Explore this box plot interactively →