ZNF428

Across TCGA pan-cancer cohorts, ZNF428 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZNF428 data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZNF428 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF428 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where ZNF428 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	II,III,IV	0.767	0.969	.015	8	view →
PDAC	OS	Tertile	II,III,IV	0.656	0.960	.023	7	view →
LUAD	OS	Tertile	III,IV	0.371	0.869	.015	6	view →
UCEC	OS	Quartile	All	1.000	0.836	.027	4	view →
LSCC	DFS	Quartile	II,III,IV	0.353	1.000	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZNF428–HNSC (OS)

Open the HNSC breakdown →