ZNF428

Across TCGA pan-cancer cohorts, ZNF428 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of ZNF428’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where ZNF428 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF428 is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

LSCC, LUAD, and CCRCC are the cancer types where ZNF428 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF428 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Female	All	+0.504	<.001	9	view →
LUAD	Male	III,IV	+0.482	<.001	8	view →
CCRCC	Male	All	−0.295	<.001	6	view →
HNSC	All	IV	+0.290	.013	4	view →
PDAC	Male	All	+0.494	.011	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

ZNF428–LSCC

Open the LSCC breakdown →