ZNF428

Across TCGA patient cohorts, ZNF428 mutation is significantly associated with the RNA expression of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF428-associated genes across cancer lineages are RNA5SP414, RNA5SP411, and RNA5SP412. Each is linked with ZNF428 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF428-to-partner and partner-to-ZNF428 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP414 grouped by ZNF428-low versus ZNF428-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF428→partner) and Y-score (partner→ZNF428) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP414 →	+1.158	+3.577	<.001	<.001	3	1
UCEC	RNA5SP411 →	+2.408	+3.393	<.001	<.001	3	1
UCEC	RNA5SP412 →	+1.169	+3.967	<.001	<.001	3	1
SKCM	RN7SKP171 →	+0.149	+7.816	<.001	.008	3	1
UCEC	UGT2B10 →	+0.298	+2.947	<.001	.003	3	1
UCEC	SLCO1B3 →	+1.052	+3.355	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

RNA5SP414 by ZNF428 expression — UCEC

Explore this box plot interactively →