Across TCGA pan-cancer cohorts, ZNF425 Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated ZNF425 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZNF425 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF425 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, KIRP, and UCEC are the cancer types where ZNF425 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.021	0.712	<.001	28	view →
KIRP	DFS	Median	All	0.037	0.920	<.001	24	view →
UCEC	DFS	Median	II,III,IV	0.937	0.300	.005	24	view →
SCLC	OS	Median	II,III,IV	0.192	0.699	.002	18	view →
DLBC	DFS	Median	IV	0.120	0.683	.001	12	view →
ESCA	DFS	Median	All	0.189	0.540	.003	12	view →
ACC	DFS	Median	III,IV	0.046	0.670	.001	12	view →
COAD	DFS	Median	III,IV	0.019	0.698	<.001	7	view →
BLCA	DFS	Median	IV	0.090	0.476	.011	6	view →
READ	DFS	Median	All	0.111	0.799	.001	6	view →
LUSC	DFS	Median	II,III,IV	0.242	0.597	.023	3	view →
SKCM	DFS	Median	III,IV	0.087	0.647	.013	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

Exploration

Same gene, other analysis: ZNF425 tumor-vs-normal RNA expression · all ZNF425 data types