Across TCGA patient cohorts, ZNF425 mutation is significantly associated with the RNA expression of many other genes, with 4,426 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF425-associated genes across cancer lineages are PPP2R2D, UHRF1, and CSTF2. Each is linked with ZNF425 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF425-to-partner and partner-to-ZNF425 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF425→partner) and Y-score (partner→ZNF425) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPP2R2D →	+0.202	+1.828	.007	.006	3	4
UCEC	UHRF1 →	+0.698	+1.794	<.001	<.001	3	3
COAD	CSTF2 →	+0.553	+2.624	<.001	.005	3	3
COAD	OIP5 →	+0.677	+2.820	<.001	.001	3	3
UCEC	MRPL37 →	+0.408	+1.784	<.001	<.001	3	3
COAD	ICMT →	+0.508	+3.906	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,426 associations by consensus.

Exploration

ZNF425 survival (RNA) · tumor vs normal (RNA) · all ZNF425 data types