ZNF425

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, ZNF425 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF425-associated genes across cancer lineages are eIF4E, FoxM1, and INPP4B. Each is linked with ZNF425 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF425-to-partner and partner-to-ZNF425 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF425→partner) and Y-score (partner→ZNF425) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADeIF4E →+0.206+3.012.014.01832
UCECFoxM1 →+0.205+1.392.016.01932
UCECINPP4B →-0.297-2.906.005.00132
UCECKu80 →+0.167+1.165.031.03532
UCECp27_pT198 →+0.093+1.415.008.04332
UCECp62 Lck ligand →+0.457+2.999<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Exploration