ZNF419

Across TCGA pan-cancer cohorts, ZNF419 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZNF419 data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ZNF419 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF419 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

LSCC, PDAC, and LUAD are the cancer types where ZNF419 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	III,IV	0.464	1.000	.005	16	view →
PDAC	OS	Tertile	II,III,IV	0.994	0.721	.002	8	view →
LUAD	DFS	Tertile	All	0.907	0.445	.023	2	view →
HNSC	DFS	Median	IV	1.000	0.924	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZNF419–LSCC (DFS)

Open the LSCC breakdown →