ZNF419

Across TCGA patient cohorts, ZNF419 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF419-associated genes across cancer lineages are eIF4E, PCNA, and ATM. Each is linked with ZNF419 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF419-to-partner and partner-to-ZNF419 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ZNF419-low versus ZNF419-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF419→partner) and Y-score (partner→ZNF419) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eIF4E →	+0.255	+2.832	.009	.035	3	3
UCEC	PCNA →	+0.233	+1.807	.008	.027	3	3
UCEC	ATM →	-0.422	-2.986	.024	.035	3	3
COAD	4E-BP1 →	+0.387	+2.815	.001	.036	2	3
UCEC	Cyclin-E1 →	+0.455	+2.321	.011	.006	3	2
UCEC	14-3-3_beta →	-0.107	-1.794	.010	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

eIF4E by ZNF419 expression — COAD

Explore this box plot interactively →