ZNF419

Across TCGA cell cohorts, ZNF419 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible ZNF419-associated genes across cancer lineages are ADAM2, SULT2A1, and SIGLEC5. Each is linked with ZNF419 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF419-to-partner and partner-to-ZNF419 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ADAM2 grouped by ZNF419-low versus ZNF419-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF419→partner) and Y-score (partner→ZNF419) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ADAM2 →	+0.023	+4.870	.004	.001	3	1
UPPER_AERODIGESTIVE_TRACT	SULT2A1 →	+0.021	+4.209	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	SIGLEC5 →	+0.017	+4.357	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	CABP5 →	+0.161	+4.510	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	FGF23 →	+0.013	+4.510	.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	ATXN3L →	+0.076	+4.510	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

ADAM2 by ZNF419 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →