Across TCGA patient cohorts, ZNF418 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF418-associated genes across cancer lineages are TFRC, ACC_pS79, and NF-kB-p65_pS536. Each is linked with ZNF418 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF418-to-partner and partner-to-ZNF418 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF418→partner) and Y-score (partner→ZNF418) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.439	+1.777	.009	.002	3	3
SKCM	ACC_pS79 →	+0.359	+3.169	.007	.017	3	2
SKCM	NF-kB-p65_pS536 →	-0.403	-2.584	.025	.011	3	2
UCEC	Cyclin-B1 →	+0.721	+2.502	<.001	.001	3	2
UCEC	Notch1 →	+0.203	+2.179	<.001	.001	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.418	-2.247	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

Exploration

ZNF418 survival (RNA) · tumor vs normal (RNA) · all ZNF418 data types