Across TCGA cell cohorts, ZNF418 mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF418-associated genes across cancer lineages are TBL1Y, LYZL2, and OR10A5. Each is linked with ZNF418 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF418-to-partner and partner-to-ZNF418 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF418→partner) and Y-score (partner→ZNF418) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TBL1Y →	+0.053	+4.643	<.001	.008	3	1
LUNG_SCLC	LYZL2 →	+0.016	+4.058	<.001	.007	3	1
LUNG_SCLC	OR10A5 →	+0.047	+3.817	<.001	.004	3	1
LUNG_SCLC	TMEM207 →	+0.554	+3.898	.001	.005	3	1
LUNG_SCLC	DPEP2NB →	+0.034	+3.898	<.001	.005	3	1
LUNG_NSCLC_LUAD	FEZF2 →	+0.010	+3.604	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Exploration

ZNF418 survival (RNA) · tumor vs normal (RNA) · all ZNF418 data types