ZNF416

Across TCGA patient cohorts, ZNF416 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF416-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and P-Cadherin. Each is linked with ZNF416 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF416-to-partner and partner-to-ZNF416 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ZNF416-low versus ZNF416-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF416→partner) and Y-score (partner→ZNF416) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.671	+2.019	<.001	.005	3	3
UCEC	EGFR_pY1068 →	-0.271	-2.807	.001	<.001	3	2
UCEC	P-Cadherin →	-0.103	-2.459	.033	.018	3	2
UCEC	C-Raf →	+0.143	+1.321	.002	.029	3	2
UCEC	Di-Ras3 →	-0.153	-2.687	.002	.005	3	2
UCEC	eEF2 →	+0.326	+1.321	.006	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Caspase-7-cleavedD198 by ZNF416 expression — UCEC

Explore this box plot interactively →