ZNF41

Across TCGA pan-cancer cohorts, ZNF41 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of ZNF41’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZNF41 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF41 is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.

THCA, CHOL, and LIHC are the cancer types where ZNF41 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF41 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.787	<.001	9	view →
CHOL	All	All	+1.296	<.001	5	view →
LIHC	All	All	+0.400	<.001	5	view →
BLCA	All	All	+0.383	.010	5	view →
LUSC	All	All	−0.285	.003	5	view →
STAD	All	II,III,IV	+0.533	.002	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

ZNF41–THCA

Open the THCA breakdown →