Across TCGA pan-cancer cohorts, ZNF407 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZNF407 data layer compared with 25 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ZNF407 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ZNF407 expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

LUAD, PDAC, and CCRCC are the cancer types where ZNF407 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Tertile	All	0.987	0.533	.010	8	view →
PDAC	DFS	Quartile	II,III,IV	0.413	0.871	.010	7	view →
CCRCC	OS	Quartile	II,III,IV	0.380	0.905	.014	2	view →
GBM	OS	Median	All	0.489	0.275	.021	2	view →
LSCC	OS	Median	All	1.000	0.800	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: ZNF407 tumor-vs-normal RNA expression · all ZNF407 data types