Across TCGA patient cohorts, ZNF407 mutation is significantly associated with the total protein of many other genes, with 57 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF407-associated genes across cancer lineages are 4E-BP1, PDCD4, and CDK1. Each is linked with ZNF407 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF407-to-partner and partner-to-ZNF407 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF407→partner) and Y-score (partner→ZNF407) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	4E-BP1 →	+0.322	+3.321	.021	.010	3	4
UCEC	PDCD4 →	-0.400	-1.169	<.001	.004	3	3
LUAD	CDK1 →	+0.127	+3.000	.012	.035	2	4
UCEC	ATM →	-0.466	-2.188	<.001	<.001	3	3
UCEC	Rad50 →	-0.146	-0.917	.017	.025	3	3
LUSC	p21 →	-0.543	-2.990	.003	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

Exploration

ZNF407 survival (RNA) · tumor vs normal (RNA) · all ZNF407 data types