Across TCGA pan-cancer cohorts, ZNF397 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZNF397 data layer compared with 26 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZNF397 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF397 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, UCEC, and SKCM are the cancer types where ZNF397 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.002	0.768	<.001	48	view →
UCEC	DFS	Median	All	1.000	0.621	.010	26	view →
SKCM	OS	Median	All	0.202	0.781	<.001	6	view →
ESCA	DFS	Median	All	0.146	0.533	.046	3	view →
LIHC	DFS	Median	II,III,IV	0.091	0.427	.040	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: ZNF397 tumor-vs-normal RNA expression · all ZNF397 data types