Across TCGA patient cohorts, ZNF397 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF397-associated genes across cancer lineages are C-Raf, EGFR_pY1068, and EGFR. Each is linked with ZNF397 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF397-to-partner and partner-to-ZNF397 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF397→partner) and Y-score (partner→ZNF397) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.190	+2.807	<.001	.003	3	2
UCEC	EGFR_pY1068 →	-0.237	-3.459	.016	.005	3	1
UCEC	EGFR →	-0.160	-2.321	.010	.034	3	1
UCEC	eIF4E →	+0.176	+2.000	.033	.010	3	1
UCEC	FoxM1 →	+0.206	+2.000	.042	.010	3	1
UCEC	JNK2 →	+0.213	+2.000	.006	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

ZNF397 survival (RNA) · tumor vs normal (RNA) · all ZNF397 data types