Across TCGA pan-cancer cohorts, ZNF395 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ZNF395 data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ZNF395 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF395 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUAD, PDAC, and UCEC are the cancer types where ZNF395 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	II,III,IV	0.266	0.844	.003	10	view →
PDAC	DFS	Tertile	III,IV	0.260	0.946	.024	10	view →
UCEC	OS	Tertile	II,III,IV	1.000	0.609	.026	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: ZNF395 tumor-vs-normal RNA expression · all ZNF395 data types