Across TCGA patient cohorts, ZNF395 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF395-associated genes across cancer lineages are PCNA, ERK2, and mTOR_pS2448. Each is linked with ZNF395 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF395-to-partner and partner-to-ZNF395 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF395→partner) and Y-score (partner→ZNF395) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.341	+3.087	<.001	<.001	3	3
UCEC	ERK2 →	+0.245	+2.115	.001	.017	3	2
UCEC	mTOR_pS2448 →	-0.176	-2.565	.003	.010	3	2
UCEC	p62 Lck ligand →	+0.581	+3.087	<.001	<.001	3	2
UCEC	PKC-delta_pS664 →	-0.102	-1.874	.034	.049	3	2
UCEC	ATM →	-0.785	-2.415	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

ZNF395 survival (RNA) · tumor vs normal (RNA) · all ZNF395 data types