ZNF394

Across TCGA pan-cancer cohorts, ZNF394 Mutation is linked to patient survival in 8 of 34 cancer types, making it a survival-associated ZNF394 data layer compared with 26 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher ZNF394 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF394 expression acts as an unfavorable survival marker.

THYM, HNSC, and COAD are the cancer types where ZNF394 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
HNSC	DFS	Median	All	0.220	0.628	.005	24	view →
COAD	DFS	Median	All	0.140	0.783	<.001	18	view →
ESCA	DFS	Median	All	0.023	0.533	<.001	18	view →
BRCA	OS	Median	III,IV	0.335	0.833	.011	12	view →
LIHC	DFS	Median	All	0.038	0.556	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
SKCM	DFS	Median	All	0.136	0.757	.006	6	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

ZNF394–THYM (OS)

Open the THYM breakdown →