ZNF394

Across TCGA patient cohorts, ZNF394 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF394-associated genes across cancer lineages are ACC_pS79, IRS1, and JNK2. Each is linked with ZNF394 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF394-to-partner and partner-to-ZNF394 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC_pS79 grouped by ZNF394-low versus ZNF394-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF394→partner) and Y-score (partner→ZNF394) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC_pS79 →	-0.294	-2.000	.030	.010	3	1
UCEC	IRS1 →	+0.205	+2.000	.011	.010	3	1
UCEC	JNK2 →	+0.170	+3.179	.029	.010	3	1
UCEC	Ku80 →	+0.205	+1.598	.026	.022	3	1
UCEC	MSH2 →	-0.226	-2.690	.012	.006	3	1
UCEC	Notch1 →	+0.171	+2.502	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

ACC_pS79 by ZNF394 expression — UCEC

Explore this box plot interactively →