ZNF385B

Across TCGA patient cohorts, ZNF385B mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF385B-associated genes across cancer lineages are PCNA, Rictor_pT1135, and Cyclin-B1. Each is linked with ZNF385B in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF385B-to-partner and partner-to-ZNF385B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ZNF385B-low versus ZNF385B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF385B→partner) and Y-score (partner→ZNF385B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.268	+3.584	<.001	.002	3	3
SKCM	Rictor_pT1135 →	-0.144	-3.296	.031	.009	3	2
UCEC	Cyclin-B1 →	+0.715	+3.807	<.001	<.001	3	2
UCEC	eIF4E →	+0.164	+3.335	.024	.005	3	2
UCEC	JNK_pT183_Y185 →	-0.158	-1.427	.006	.024	3	2
UCEC	mTOR_pS2448 →	-0.137	-2.209	.008	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

PCNA by ZNF385B expression — UCEC

Explore this box plot interactively →