ZNF382

Across TCGA pan-cancer cohorts, ZNF382 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ZNF382’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZNF382 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF382 is over-expressed in tumor, although a few such as THCA and READ show the opposite, repressed pattern.

THCA, KIRC, and LIHC are the cancer types where ZNF382 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF382 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	III,IV	−0.430	<.001	10	view →
KIRC	Male	All	+0.326	<.001	7	view →
LIHC	Female	II,III,IV	+0.381	<.001	6	view →
BRCA	All	II,III,IV	+0.299	<.001	6	view →
CHOL	All	All	+0.547	<.001	2	view →
KIRP	Female	All	+0.500	.011	2	view →
READ	All	All	−0.452	.023	2	view →
UCEC	All	All	−0.263	.037	2	view →
PRAD	All	All	+0.214	<.001	2	view →
COAD	All	All	−0.149	.012	2	view →
BLCA	Male	IV	−0.740	.036	1	view →
LUAD	Male	All	+0.324	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

ZNF382–THCA

Open the THCA breakdown →