ZNF366

Across TCGA patient cohorts, ZNF366 mutation is significantly associated with the RNA expression of many other genes, with 3,926 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF366-associated genes across cancer lineages are SNRPEP3, TRAJ36, and SLC25A28. Each is linked with ZNF366 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF366-to-partner and partner-to-ZNF366 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNRPEP3 grouped by ZNF366-low versus ZNF366-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF366→partner) and Y-score (partner→ZNF366) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	SNRPEP3 →	+0.237	+3.968	.004	.006	3	3
LGG	TRAJ36 →	+0.347	+6.061	<.001	<.001	3	3
UCEC	SLC25A28 →	+0.244	+1.283	.001	.005	3	3
UCEC	CHAF1B →	+0.417	+1.732	.002	.002	3	3
UCEC	CHCHD4 →	+0.327	+1.831	<.001	.002	3	3
UCEC	PDGFD →	-0.505	-1.251	.009	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,926 associations by consensus.

SNRPEP3 by ZNF366 expression — LGG

Explore this box plot interactively →