ZNF366

Across TCGA patient cohorts, ZNF366 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF366-associated genes across cancer lineages are p27_pT157, Src_pY527, and Caspase-7-cleavedD198. Each is linked with ZNF366 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF366-to-partner and partner-to-ZNF366 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT157 grouped by ZNF366-low versus ZNF366-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF366→partner) and Y-score (partner→ZNF366) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p27_pT157 →	+0.147	+2.246	.002	.030	3	3
UCEC	Src_pY527 →	-0.334	-1.405	.011	.043	3	2
UCEC	Caspase-7-cleavedD198 →	+0.824	+2.247	<.001	.001	3	2
UCEC	Chk2_pT68 →	-0.152	-2.160	.007	.003	3	2
UCEC	c-Kit →	-0.171	-1.565	.016	.017	3	2
UCEC	4E-BP1 →	+0.197	+2.584	.017	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

p27_pT157 by ZNF366 expression — SKCM

Explore this box plot interactively →