ZNF365

Across TCGA patient cohorts, ZNF365 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF365-associated genes across cancer lineages are CD49b, C-Raf, and Bak. Each is linked with ZNF365 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF365-to-partner and partner-to-ZNF365 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD49b grouped by ZNF365-low versus ZNF365-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF365→partner) and Y-score (partner→ZNF365) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CD49b →	+0.289	+3.000	.049	.035	3	3
UCEC	C-Raf →	+0.126	+2.459	.004	.018	3	3
LUAD	Bak →	+0.161	+3.033	.005	.018	3	2
UCEC	Rab25 →	-0.367	-3.906	<.001	<.001	3	2
COAD	GAPDH →	+0.788	+3.178	.001	.010	3	2
COAD	mTOR_pS2448 →	-0.203	-2.987	.021	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

CD49b by ZNF365 expression — COAD

Explore this box plot interactively →