ZNF362

Across TCGA pan-cancer cohorts, ZNF362 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZNF362 data layer compared with 25 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ZNF362 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ZNF362 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LSCC, CCRCC, and PDAC are the cancer types where ZNF362 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	III,IV	0.940	0.440	.004	33	view →
CCRCC	DFS	Quartile	III,IV	1.000	0.622	.015	9	view →
PDAC	OS	Quartile	All	0.533	1.000	.022	6	view →
LUAD	DFS	Median	III,IV	0.432	0.925	.047	3	view →
HNSC	OS	Tertile	All	1.000	0.941	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZNF362–LSCC (OS)

Open the LSCC breakdown →