ZNF362

Across TCGA patient cohorts, ZNF362 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF362-associated genes across cancer lineages are Chk2_pT68, FoxM1, and mTOR_pS2448. Each is linked with ZNF362 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF362-to-partner and partner-to-ZNF362 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chk2_pT68 grouped by ZNF362-low versus ZNF362-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF362→partner) and Y-score (partner→ZNF362) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Chk2_pT68 →	-0.164	-3.674	.008	.001	3	3
UCEC	FoxM1 →	+0.179	+1.321	.039	.029	3	2
UCEC	mTOR_pS2448 →	-0.145	-2.209	.003	.009	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.405	-1.906	.007	.015	3	2
UCEC	PRDX1 →	+0.174	+2.000	.011	.009	3	2
UCEC	eEF2 →	+0.355	+2.584	.003	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Chk2_pT68 by ZNF362 expression — UCEC

Explore this box plot interactively →