Across TCGA patient cohorts, ZNF358 mutation is significantly associated with the RNA expression of many other genes, with 2,265 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF358-associated genes across cancer lineages are TRAJ47, LINC00489, and TIMM44. Each is linked with ZNF358 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF358-to-partner and partner-to-ZNF358 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF358→partner) and Y-score (partner→ZNF358) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRAJ47 →	+0.405	+1.825	<.001	.007	3	3
HNSC	LINC00489 →	+0.095	+6.111	<.001	.002	3	3
UCEC	TIMM44 →	+0.446	+2.354	<.001	<.001	3	3
UCEC	NCLN →	+0.392	+2.262	.008	.005	3	3
UCEC	PPAT →	+0.677	+3.595	<.001	.001	3	3
UCEC	PLD6 →	+0.494	+1.958	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,265 associations by consensus.

Exploration

ZNF358 survival (RNA) · tumor vs normal (RNA) · all ZNF358 data types