Across TCGA patient cohorts, ZNF358 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF358-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and Ku80. Each is linked with ZNF358 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF358-to-partner and partner-to-ZNF358 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF358→partner) and Y-score (partner→ZNF358) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+1.102	+3.807	<.001	<.001	3	2
UCEC	4E-BP1 →	+0.267	+2.000	.012	.010	3	2
UCEC	Ku80 →	+0.270	+2.013	.003	.005	3	1
UCEC	MSH2 →	-0.238	-2.295	.008	.033	3	1
UCEC	MSH6 →	-0.329	-3.169	.011	.018	3	1
UCEC	Notch1 →	+0.177	+1.887	.001	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Exploration

ZNF358 survival (RNA) · tumor vs normal (RNA) · all ZNF358 data types