Across TCGA cell cohorts, ZNF358 mutation is significantly associated with the RNA expression of many other genes, with 351 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF358-associated genes across cancer lineages are SLC10A2, GCAT, and ANKRD54. Each is linked with ZNF358 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF358-to-partner and partner-to-ZNF358 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF358→partner) and Y-score (partner→ZNF358) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SLC10A2 →	+0.005	+5.022	<.001	.002	3	1
LARGE_INTESTINE	GCAT →	+1.435	+3.743	<.001	<.001	3	1
LARGE_INTESTINE	ANKRD54 →	+0.528	+2.714	<.001	.002	3	1
LARGE_INTESTINE	CBY1 →	+0.598	+3.330	<.001	.002	3	1
LARGE_INTESTINE	HMGXB4 →	+0.507	+2.628	.004	.002	3	1
LARGE_INTESTINE	MIEF1 →	+0.556	+2.628	.007	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 351 associations by consensus.

Exploration

ZNF358 survival (RNA) · tumor vs normal (RNA) · all ZNF358 data types