ZNF354B

Across TCGA pan-cancer cohorts, ZNF354B Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZNF354B data layer compared with 22 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ZNF354B Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF354B expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

ACC, LIHC, and UCEC are the cancer types where ZNF354B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.010	0.667	<.001	45	view →
LIHC	OS	Median	All	0.174	0.694	<.001	30	view →
UCEC	DFS	Median	All	0.968	0.621	.006	30	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	9	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZNF354B–ACC (DFS)

Open the ACC breakdown →