ZNF354B

Across TCGA patient cohorts, ZNF354B mutation is significantly associated with the RNA expression of many other genes, with 3,777 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF354B-associated genes across cancer lineages are H4C7, RN7SL66P, and PPIL2. Each is linked with ZNF354B in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF354B-to-partner and partner-to-ZNF354B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H4C7 grouped by ZNF354B-low versus ZNF354B-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF354B→partner) and Y-score (partner→ZNF354B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	H4C7 →	+0.113	+5.008	<.001	.004	3	2
CESC	RN7SL66P →	+0.158	+5.010	<.001	.009	3	2
UCEC	PPIL2 →	+0.339	+1.765	<.001	<.001	3	2
UCEC	MCM5 →	+0.548	+2.283	<.001	<.001	3	2
UCEC	ALKBH1 →	+0.339	+2.633	<.001	<.001	3	2
UCEC	E2F1 →	+0.756	+4.141	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,777 associations by consensus.

H4C7 by ZNF354B expression — LIHC

Explore this box plot interactively →