ZNF354B

Across TCGA patient cohorts, ZNF354B mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF354B-associated genes across cancer lineages are EGFR_pY1068, ACC1, and TFRC. Each is linked with ZNF354B in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF354B-to-partner and partner-to-ZNF354B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ZNF354B-low versus ZNF354B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF354B→partner) and Y-score (partner→ZNF354B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.221	-1.584	.005	.017	3	2
UCEC	ACC1 →	+0.349	+2.235	.002	.005	3	2
UCEC	TFRC →	+0.474	+1.523	.005	.008	3	2
UCEC	Caspase-7-cleavedD198 →	+0.674	+2.682	<.001	<.001	3	2
UCEC	14-3-3_beta →	-0.102	-2.295	.001	.005	3	1
UCEC	eIF4E →	+0.247	+2.058	<.001	<.001	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

EGFR_pY1068 by ZNF354B expression — UCEC

Explore this box plot interactively →