ZNF354B

Across TCGA cell cohorts, ZNF354B mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF354B-associated genes across cancer lineages are XAGE5, GJD2, and MC2R. Each is linked with ZNF354B in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF354B-to-partner and partner-to-ZNF354B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, XAGE5 grouped by ZNF354B-low versus ZNF354B-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF354B→partner) and Y-score (partner→ZNF354B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	XAGE5 →	+0.255	+5.196	<.001	.005	3	1
BLOOD_Leukemia	GJD2 →	+0.055	+4.152	<.001	.009	3	1
BLOOD_Leukemia	MC2R →	+0.004	+4.969	<.001	.003	3	1
LARGE_INTESTINE	TRPA1 →	+0.629	+3.362	<.001	.006	3	1
LARGE_INTESTINE	LY86 →	+0.042	+2.772	.007	.005	3	1
LARGE_INTESTINE	ALKBH7 →	+0.529	+3.064	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

XAGE5 by ZNF354B expression — OVARY

Explore this box plot interactively →