ZNF354A

Across TCGA patient cohorts, ZNF354A mutation is significantly associated with the RNA expression of many other genes, with 4,637 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF354A-associated genes across cancer lineages are MRM3, RNA5SP35, and YWHAE. Each is linked with ZNF354A in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF354A-to-partner and partner-to-ZNF354A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRM3 grouped by ZNF354A-low versus ZNF354A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF354A→partner) and Y-score (partner→ZNF354A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRM3 →	+0.397	+2.421	<.001	<.001	3	3
READ	RNA5SP35 →	+0.389	+5.653	<.001	.003	3	3
UCEC	YWHAE →	+0.314	+2.410	.002	<.001	3	3
COAD	LINC01022 →	+0.220	+2.462	.004	.008	3	3
UCEC	PTPRJ →	+0.557	+1.534	.001	.005	3	2
UCEC	SLC7A11 →	+0.801	+2.058	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,637 associations by consensus.

MRM3 by ZNF354A expression — UCEC

Explore this box plot interactively →